The Journal of Theoretical Fimpology. Volume 1, Issue 1: e-20120612-2. March 18, 2013 (www.fimpology.com)
ORCID ID: https://orcid.org/0009-0005-8661-6889
Abstract
The existing literatures newly indicated that (i) fetal cells are physiologically present in maternal blood and other multiple maternal tissues and organs during pregnancy and after delivery; (ii) different functional immune cells and stem cells were found in human breastmilk; and (iii) intact animal milkcells can migrate into the gut wall of suckling offspring and distribute further over the animal neonatal body. Based on the above advantages, the author proposes a novel model called Fetus-Breastmilk-Breastfeeding-Infant-Cells Cycle (FBBIC Cycle), or fetus-to-infant his/her own fetal cell external transmission for revealing an unrecognized mechanism, in which some stem cells and functional immune cells derived from embryonic/fetal cells become the partial of milkcells and can be withdrew by breastfed infants; and the regained fetal cells could further re-spread within the suckling body without potential allogenic or semi-allogenic problems. The completion of FBBIC Cycle depends on the continuity from gestation to lactation. The FBBIC Cycle theory for the first time proposes that fetus may be a milkcell-contributor; and moreover, the acquired cellular immunity during pregnancy may be transferred to the suckling via FBBIC Cycle. The hypothetic benefits of FBBIC Cycle in immunology and regenerative cytology merits further appraisal.