The Journal of Theoretical Fimpology. Volume 1, Issue 2: e-20120609-1-2-3. May 18, 2013 (www.fimpology.com)
Shu-dong Yin
ORCID ID: https://orcid.org/0009-0005-8661-6889
Cory H. E. R. & C. Inc., Burnaby, British Columbia, Canada
Email: [email protected]
Abstract
Pregnancy-associated cell transmission among fetus, mother and infant has attracted more and more attention during the past decades, among which, fetus-to-maternal cell transmission (FMCT) and maternal-to-fetal cell transmission (MFCT) are the two most studied. Recently, a novel model called fetus-breastmilk-breastfeeding-infant-cells cycle (FBBIC Cycle) has been proposed, which uncovered an unrecognized embryonic/fetal cell migration for the transmission of eukaryotic cells from fetus to infant him/herself via breastmilk and breastfeeding. Up to now, total six models: (i) FMCT, (ii) MFCT, (iii) gestation-associated fetus-to-fetus cell transmission (FFCT), (iv) breastmilk and breastfeeding-mediated maternal-to-infant cell transmission (MICT), (v) breastmilk and breastfeeding-mediated fetus-to-infant allogenic or inter-sibling cell transmission (FICT), and (vi) FBBIC Cycle constitute a complex system of eukaryotic cell exchange and interaction among mother, fetus and suckling infant during gestation and lactation. Among these pregnancy-associated models, FBBIC Cycle should be the major melody because only it reflects the most benefit of offspring during his/her prenatal and postnatal life in the physiological and immunological perspective without potential disadvantages introduced by allogenic and semi-allogenic cells. A thoroughly theoretical exploration in fimpology is essential to accurately interpreting prenatal diagnosis, making further development of molecular diagnostic techniques and deeply elucidating tolerogenic mechanisms in transplantation immunology.